Ascorbyl palmitate–PCL fiber mats loaded with strontium polyphosphate nanoparticles for guided bone regeneration

Abstract Multifunctional fiber mats are explored as potential bioactive matrices for the development of next generation guided bone regeneration membranes with tunable microstructure, strength and therapeutic activity. In present study, polycaprolactone (PCL) nanofibers different concentrations ascorbic acid derivatives (ascorbyl palmitate) strontium polyphosphate nanoparticles (Sr-polyP NPs) were fabricated. The obtained PCL scaffolds assessed not only microstructure structure features, including morphological observation, hydrophilicity tensile strength, but also in vitro water uptake, biodegradation (under enzymatic hydrolytic conditions), bioactivity using SBF, well release study. observed results showed that mean diameter fibers (388 ± 340 nm) increased increase concentration ASP Sr-polyP NPs. addition ascorbyl palmitate caused an viscosity from 40.6 2.5 to 66.6 2.0 cP case 20% AsP/PCL; however, it a decrease conductivity 7.3 0.4 6.38 µs, while there was obvious by Nps 88.3 PA1/SP 15 . contact angle decreases 125.9 ° 112 4 102 2.4 loaded palmitate-PCL 15% Sr/PCL, respectively. Moreover, assessment antioxidant activity containing 10% demonstrated have higher effectiveness compared mats. This could be attributed controlled PCL, which occurs after 7 days. However, highest 5% NPs-loaded PCL/AsP at 1.52 0.51 MPa. Further NPs content resulted clear 1.13 0.13and 0.93 0.71 mats, Importantly, fabricated AsP induction calcium phosphate deposition SBF ability sustain over time period 28 d, enhancement cell proliferation suggesting their application favorable synthetic matrix amplify process. Graphical abstract